She is the oldest daughter of Ishtar family. Her native has responsibility taking care of Pharaoh's tomb. Isis realizes that her brother is controlled by a shadow mind created by his hatre against his father. In order to save her brother and take a god card back from him, Isis asks Kaiba to open the tournament and joins it.

By mysterious character and adulthood, she makes Kaiba be in trouble during their duel. Also, she is an owner of a millennium tauk both at present and 3,000 years ago.